This roundtable will explore how pharmacy-enabled neighbourhood teams can deliver integrated, patient-centred care for people at risk of cardiovascular, renal, metabolic conditions, and obesity. The discussion will focus on building pharmacy capacity, including independent prescribing, diagnostic access, data visibility, and patient coaching, while aligning time and incentives with meaningful outcomes. The session will examine medicines optimisation, standardising protocols for initiation, titration, and deprescribing, and ensuring the right medicines reach the right patients at the right time. It will also highlight digital and data enablers for shared care planning, real-time collaboration, and coordinated care, while considering how national policy and incentives can support or hinder progress.A population-health perspective will underpin the discussion, strengthening pharmacists’ leadership, enhancing pharmacy technicians’ roles, and driving improvements in long-term condition management in line with the NHS 10-Year Plan.